• Corpus ID: 18077590

Lipid composition of the normal human brain: gray matter, white matter, and myelin.

@article{Obrien1965LipidCO,
  title={Lipid composition of the normal human brain: gray matter, white matter, and myelin.},
  author={John S. O'brien and E. Lois Sampson},
  journal={Journal of lipid research},
  year={1965},
  volume={6 4},
  pages={
          537-44
        }
}
SUMMARY Gray matter, white matter, and myelin were isolated from the frontal lobes of humans aged 10 months, 6 yr, 9 yr, and 55 yr and the lipid compositions of each were determined. Myelin had a much higher lipid content (7841% of the dry weight) than white matter (49-66%) or gray matter (36-400/,). Myelin contained much higher molar percentages of cerebroside and cerebroside sulfate, slightly higher molar percentages of cholesterol, and lower molar percentages of ethanolamine… 
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Background Citations
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Lipid and fatty acid composition of human cerebral myelin during development.

The fatty acid changes during development were much more pronounced in white matter than in myelin but already from 1-2 years of age the lipids of myelin and white matter had the same patterns--in the galactolipids from 2 months of age.

LIPID COMPOSITION OF HUMAN CEREBRAL WHITE MATTER AND MYELIN IN PHENYLKETONURIA 1

The finding in PKU brains of a normal composition of lipids in the purified myelin and the absence of cholesterol esters in the white matter suggest that the deficiency in myelin may reflect an early arrest of myelination.

LIPID COMPOSITION OF OPTIC NERVE MYELIN

Myelin was isolated from bovine optic nerves by differential ultracentrifugation and its lipid composition was analysed, and Optic nerve myelin resembled one another closely in overall lipid composition and in the fatty acid compositions of their constituent lipids.

CHANGES IN FATTY ACID COMPOSITION OF HUMAN BRAIN MYELIN LIPIDS DURING MATURATION 1

The variation with age of the fatty acid composition of the major lipids in human brain myelin was compared with that of cerebral white matter from the same region and the proportions of cholesterol and especially of the galactolipids increased in myelin during the first 6 months, and in cerebralwhite matter up to 2 years.

THE LIPID COMPOSITION OF AXONS FROM BOVINE BRAIN 1

Bovine axons derived from myelinated CNS axons were found to have 13.5% lipid, with a decreased contribution by gangliosides GT1 and GD1b relative toganglioside distributions which have been reported for most other CNS components.

Phospholipids and acyl groups in subcellular fractions from human cerebral cortex.

  • G. Sun
  • Chemistry, Biology
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  • 1973
The brain lipid composition in normal human subjects is rather constant and does not seem to be affected much by individual variations.

LIPID COMPOSITION OF MYELIN FROM THE PERIPHERAL NERVOUS SYSTEM

The present report is concerned with the isolation of PNS myelin in pure form from bovine intradural spinal roots, the quantification of the major lipid classes present in this myelin preparation, and the analyses of the fatty acid and fatty aldehyde composition of each major lipid class.

FATTY ACID AND FATTY ALDEHYDE COMPOSITION OF GLIAL CELL LIPIDS ISOLATED FROM BOVINE WHITE MATTER

Glial cells were isolated from bovine white matter by differential centrifugation and long‐chain fatty acids were detected in sphingomyelin, cerebroside and cerebro side sulphate; this indicates that chain‐elongation beyond C18 occurs in the glial cells.

Biochemical maturation of the central nervous system. I. Lipid changes.

...

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