Lipid composition of guinea pig platelets and megakaryocytes. The megakaryocyte as a probable source of platelet lipids.

@article{Schick1981LipidCO,
  title={Lipid composition of guinea pig platelets and megakaryocytes. The megakaryocyte as a probable source of platelet lipids.},
  author={Barbara P. Schick and Paul K. Schick and Peter Chase},
  journal={Biochimica et biophysica acta},
  year={1981},
  volume={663 1},
  pages={239-48}
}
Platelets are formed by fragmentation of the cytoplasm and plasma membrane of the megakaryocyte in the bone marrow. This study has compared the lipid composition of guinea pig platelets and megakaryocytes. Phospholipids were quantitated by TLC and measurement of lipid phosphorus. Cholesterol and fatty acids were quantitated by GLC. The cholesterol/phospholipid molar distribution in megakaryocytes was: 9.8% phosphatidylserine, 6.7% phosphatidylinositol, 14.2% sphingomyelin, 40.0… CONTINUE READING