Lipid composition is an important determinant of antimicrobial activity of alpha-melanocyte stimulating hormone.

Abstract

We have reported strong antimicrobial activity of cationic neuropeptide α-MSH against Staphylococcus aureus. Clinical S. aureus isolates non-susceptible to the peptide had higher amount of cationic phospholipid. To elucidate the molecular basis of lipid selectivity and antimicrobial activity of α-MSH, studies were carried out on SUVs having different… (More)
DOI: 10.1016/j.bpc.2014.09.002

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