Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester.

@article{Bacon2007LipidCA,
  title={Lipid composition and transcriptional response of Mycobacterium tuberculosis grown under iron-limitation in continuous culture: identification of a novel wax ester.},
  author={Joanna Bacon and Lynn George Dover and Kim A. Hatch and Yi Zhang and J{\'e}ssica Marcela de Luna Gomes and Sharon L. Kendall and Lorenz Wernisch and Neil G. Stoker and Philip D. Butcher and Gurdyal S Besra and Philip David Marsh},
  journal={Microbiology},
  year={2007},
  volume={153 Pt 5},
  pages={1435-44}
}
The low level of available iron in vivo is a major obstacle for microbial pathogens and is a stimulus for the expression of virulence genes. In this study, Mycobacterium tuberculosis H37Rv was grown aerobically in the presence of limited iron availability in chemostat culture to determine the physiological response of the organism to iron-limitation. A previously unidentified wax ester accumulated under iron-limited growth, and changes in the abundance of triacylglycerol and menaquinone were… CONTINUE READING