Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1.

@article{Matyas2009LipidBP,
  title={Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1.},
  author={G. Matyas and Z. Beck and N. Karasavvas and C. Alving},
  journal={Biochimica et biophysica acta},
  year={2009},
  volume={1788 3},
  pages={
          660-5
        }
}
Two human mAbs (2F5 and 4E10), originally derived from HIV-1-infected patients, are important, but rare, mAbs that exhibit broad cross-clade neutralizing activities against HIV-1. In addition to peptide sequences on the gp41 envelope protein, both antibodies reportedly also bound specifically to several phospholipid antigens. However, the phospholipid binding property of 2F5 has been disputed and, because of uncertainly regarding phospholipid binding, the modeling of neutralizing mechanisms has… Expand
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The similarity of 2F5 and 4E10 mAbs to known anti-cardiolipin Abs is compared and the model that mAb 2f5 and4E10 binding to HIV-1 involves both viral lipid membrane and gp41 membrane proximal epitopes is supported. Expand
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TLDR
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TLDR
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TLDR
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HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane.
TLDR
How BNAbs may perturb tryptophan residue-associated viral fusion involving the mobile N-terminal MPER segment and, given conservation of MPER sequences in HIV-1, HIV-2, and SIV, have important implications for structure-guided vaccine design are suggested. Expand
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TLDR
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