Lipid-bilayer permeation of drug-like compounds.

Abstract

Lipid-bilayer permeation is determinant for the disposition of xenobiotics in the body. It controls the pharmacokinetic behavior of drugs and is, in many cases, a prerequisite for intracellular targeting. Permeation of in vivo barriers is in general predicted from lipophilicity and related parameters. This article goes beyond the empirical correlations, and… (More)
DOI: 10.1002/cbdv.200900122

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