Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USA.

@article{Dougherty1987LipidAP,
  title={Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USA.},
  author={R. M. Dougherty and Claudio Galli and Anna Ferro-Luzzi and J. M. Iacono},
  journal={The American journal of clinical nutrition},
  year={1987},
  volume={45 2},
  pages={
          443-55
        }
}
A pilot study was conducted of males 40-45 years old from rural areas of three countries to study the long-term effects of dietary fats on the lipids of plasma, red blood cells (RBCs), and platelets. Differences were observed in cholesterol and phospholipid levels of plasma. Total phospholipids of RBCs and platelets were similar in all three countries. The pattern of individual phospholipids of RBCs in the Finnish and Italian samples differed from the American samples. In all plasma and RBC… 
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References

SHOWING 1-10 OF 51 REFERENCES
Composition of phospholipids and of phospholipid fatty acids of human plasma.
TLDR
The high percentage of unsaturated fatty acids found in plasma lysolecithin suggests that this phospholipid did not arise entirely through the enzymatic cleavage of the -fatty acid of leCithin, although some marked differences in individual fatty acid levels between the corresponding phospholips of plasma and red cells were evident.
Modification of human platelet function by a diet enriched in saturated or polyunsaturated fat.
Effect of a diet low in saturated fatty acids on plasma lipids, lipoproteins, and HDL subfractions.
TLDR
It is concluded that a low-fat, high-P/S ratio diet lowers LDL and HDL2 cholesterol in healthy volunteers, but does not influence the level of HDL3 subfraction.
The effect of aspirin and linoleic acid on platelet aggregation, platelet fatty acid composition and haemostasis in man.
TLDR
The Wellcome whole blood aggregometer is a sensitive test of platelet function and linoleic acid has been shown to reduce aggregation in conjunction with an increase in polyunsaturated fatty acid content of the platelet membrane.
Influence of dietary fats on atherosclerosis, coagulation and platelet phospholipids in rabbits.
Relationship between Fatty‐Acid Composition of Platelets and Platelet Aggregation in Rat and Man: RELATION TO THROMBOSIS
TLDR
In both the rat and man, a high thrombotic tendency may be associated with a platelet hypersusceptibility to thrombin which, in turn, is related to changes in fatty-acid composition.
Red blood cell fatty acid composition in a sample of Italian middle-aged men on free diet.
TLDR
A negative correlation was observed between erythrocyte linoleic/oleic ratio and plasma cholesterol levels, which gives indirect support to the validity of this ratio as an index of adherence to cholesterol-lowering diets in long-term studies.
EFFECTS OF 11-WEEK INCREASE IN DIETARY EICOSAPENTAENOIC ACID ON BLEEDING TIME, LIPIDS, AND PLATELET AGGREGATION
Effects of alcohol ingestion on lipids and lipoproteins in normal men: isocaloric metabolic studies.
TLDR
Alcohol's effect on C-HDL and triglyceride probably involves an interaction with total calories, and perhaps with dietary composition (cholesterol, saturated fat, carbohydrate content), as well as the amount of ethanol ingested, and duration of intake.
Changing the Mediterranean diet: effects on blood lipids.
TLDR
A study was carried out on 48 healthy middle-age men and women habitually subsisting on a "Mediterranean type" diet in a rural area of southern Italy, modified for a period of 42 days by partially substituting animal fats for olive oil, and the subjects maintained their habitual lifestyle.
...
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