Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USA.

@article{Dougherty1987LipidAP,
  title={Lipid and phospholipid fatty acid composition of plasma, red blood cells, and platelets and how they are affected by dietary lipids: a study of normal subjects from Italy, Finland, and the USA.},
  author={R. Dougherty and C. Galli and A. Ferro-Luzzi and J. Iacono},
  journal={The American journal of clinical nutrition},
  year={1987},
  volume={45 2},
  pages={
          443-55
        }
}
A pilot study was conducted of males 40-45 years old from rural areas of three countries to study the long-term effects of dietary fats on the lipids of plasma, red blood cells (RBCs), and platelets. Differences were observed in cholesterol and phospholipid levels of plasma. Total phospholipids of RBCs and platelets were similar in all three countries. The pattern of individual phospholipids of RBCs in the Finnish and Italian samples differed from the American samples. In all plasma and RBC… Expand
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References

SHOWING 1-10 OF 52 REFERENCES
Composition of phospholipids and of phospholipid fatty acids of human plasma.
TLDR
The high percentage of unsaturated fatty acids found in plasma lysolecithin suggests that this phospholipid did not arise entirely through the enzymatic cleavage of the -fatty acid of leCithin, although some marked differences in individual fatty acid levels between the corresponding phospholips of plasma and red cells were evident. Expand
The effect of diet on the phospholipid composition of the red blood cells of man
TLDR
Red cells from subjects on a diet rich in corn oil were found to contain higher levels of linoleic acid in the lecithin and phosphatidyl serine fractions, and lower levels of oleic acid In the leCithin fraction, and it is probable that these alterations represent the result of highly specific exchanges with plasma fatty acids. Expand
Modification of human platelet function by a diet enriched in saturated or polyunsaturated fat.
TLDR
Results indicate that platelets may be activated in apparently normal people consuming a SF diet and that this activation may be decreased by replacement of dietary SF with PUF. Expand
Platelet functions in relation to diet and serum lipids in British farmers.
TLDR
In this study, platelet functions were more dependent upon the dietary factors associated with coronary heart disease such as saturated fats, calcium, and alcohol than upon serum lipids. Expand
Effect of a diet low in saturated fatty acids on plasma lipids, lipoproteins, and HDL subfractions.
TLDR
It is concluded that a low-fat, high-P/S ratio diet lowers LDL and HDL2 cholesterol in healthy volunteers, but does not influence the level of HDL3 subfraction. Expand
The effect of aspirin and linoleic acid on platelet aggregation, platelet fatty acid composition and haemostasis in man.
TLDR
The Wellcome whole blood aggregometer is a sensitive test of platelet function and linoleic acid has been shown to reduce aggregation in conjunction with an increase in polyunsaturated fatty acid content of the platelet membrane. Expand
Influence of dietary fats on atherosclerosis, coagulation and platelet phospholipids in rabbits.
TLDR
Butter was the only fat able to induce severe alterations at the same time in coagulation (presumably through an increase in the activity of certain platelet phospholipids), lipemia and arterial wall morphology. Expand
Relationship between Fatty‐Acid Composition of Platelets and Platelet Aggregation in Rat and Man: RELATION TO THROMBOSIS
TLDR
In both the rat and man, a high thrombotic tendency may be associated with a platelet hypersusceptibility to thrombin which, in turn, is related to changes in fatty-acid composition. Expand
Red blood cell fatty acid composition in a sample of Italian middle-aged men on free diet.
TLDR
A negative correlation was observed between erythrocyte linoleic/oleic ratio and plasma cholesterol levels, which gives indirect support to the validity of this ratio as an index of adherence to cholesterol-lowering diets in long-term studies. Expand
EFFECTS OF 11-WEEK INCREASE IN DIETARY EICOSAPENTAENOIC ACID ON BLEEDING TIME, LIPIDS, AND PLATELET AGGREGATION
TLDR
A diet rich in omega-3 polyunsaturated fatty acids reduces the interaction between platelets and the vessel wall by mechanisms which are more complex than just a reduction in susceptibility of platelets to the naturally occurring agents collagen and ADP, or an imbalance between proaggregatory and anti-aggRegatory prostaglandin derivatives. Expand
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1
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3
4
5
...