Lipid and phase specificity of α-toxin from S. aureus.

Abstract

The pore forming toxin Hla (α-toxin) from Staphylococcus aureus is an important pathogenic factor of the bacterium S. aureus and also a model system for the process of membrane-induced protein oligomerisation and pore formation. It has been shown that binding to lipid membranes at neutral or basic pH requires the presence of a phosphocholine-headgroup. Thus… (More)
DOI: 10.1016/j.bbamem.2013.04.005

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