Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods.

@article{Fuster2004LipidAM,
  title={Lipid- and mechanosensitivities of sodium/hydrogen exchangers analyzed by electrical methods.},
  author={Daniel G Fuster and Orson W Moe and Donald W Hilgemann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 28},
  pages={10482-7}
}
Sodium/hydrogen exchangers (NHEs) are ubiquitous ion transporters that serve multiple cell functions. We have studied two mammalian isoforms, NHE1 (ubiquitous) and NHE3 (epithelial-specific), by measuring extracellular proton (H+) gradients during whole-cell patch clamp with perfusion of the cell interior. Maximal Na(+)-dependent H+ fluxes (JH+) are equivalent to currents >20 pA for NHE1 in Chinese hamster ovary fibroblasts, >200 pA for NHE1 in guinea pig ventricular myocytes, and 5-10 pA for… CONTINUE READING
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