Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion*

  title={Lipid-anchored Synaptobrevin Provides Little or No Support for Exocytosis or Liposome Fusion*},
  author={Che-Wei Chang and Chung-Wei Chiang and Jon D. Gaffaney and Edwin R. Chapman and Meyer B. Jackson},
  journal={The Journal of Biological Chemistry},
  pages={2848 - 2857}
SNARE proteins catalyze many forms of biological membrane fusion, including Ca2+-triggered exocytosis. Although fusion mediated by SNAREs generally involves proteins anchored to each fusing membrane by a transmembrane domain (TMD), the role of TMDs remains unclear, and previous studies diverge on whether SNAREs can drive fusion without a TMD. This issue is important because it relates to the question of the structure and composition of the initial fusion pore, as well as the question of whether… 

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