Lipid Signaling in Experimental Epilepsy

  title={Lipid Signaling in Experimental Epilepsy},
  author={Kasie K. Cole-Edwards and Nicolas G Bazan},
  journal={Neurochemical Research},
Glutamate release activates signaling pathways important for learning and memory, and over-stimulation of these pathways during seizures leads to aberrant synaptic plasticity associated with hyper-excitable, seizure-prone states. Seizures induce rapid accumulation of membrane lipid-derived fatty acids at the synapses which, evidence suggests, regulate maladaptive connectivity. Here we give an overview of the significance of the arachidonyl- and inositol-derived messengers, prostaglandins (PGs… CONTINUE READING


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