Lipid Raft-Mediated Regulation of G-Protein Coupled Receptor Signaling by Ligands which Influence Receptor Dimerization: A Computational Study

@inproceedings{FallahiSichani2009LipidRR,
  title={Lipid Raft-Mediated Regulation of G-Protein Coupled Receptor Signaling by Ligands which Influence Receptor Dimerization: A Computational Study},
  author={Mohammad Fallahi-Sichani and Jennifer J. Linderman},
  booktitle={PloS one},
  year={2009}
}
G-protein coupled receptors (GPCRs) are the largest family of cell surface receptors; they activate heterotrimeric G-proteins in response to ligand stimulation. Although many GPCRs have been shown to form homo- and/or heterodimers on the cell membrane, the purpose of this dimerization is not known. Recent research has shown that receptor dimerization may have a role in organization of receptors on the cell surface. In addition, microdomains on the cell membrane termed lipid rafts have been… CONTINUE READING

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Receptors: Models for binding, trafficking, and signaling

  • D Lauffenburger, JJ Linderman
  • 1993
Highly Influential
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