Lipid-Nucleic Acid Supramolecular Complexes : Lipoplex Structure and the Kinetics of Formation

The need for synthetic gene therapy or gene silencing vehicles that can insert therapeutic nucleic acids (DNA or siRNA) into cells (so-called transfection) has focused interest on lipid-nucleic acid assemblies (lipoplexes). This paper reviews the kinetics pathways leading to lipoplex formation and structure. The process is qualitatively comparable to those… CONTINUE READING