Lipid Metabolism: Ceramide Transfer Protein Adds a New Dimension

@article{Hannun2004LipidMC,
  title={Lipid Metabolism: Ceramide Transfer Protein Adds a New Dimension},
  author={Yusuf A. Hannun and Chiara Luberto},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={R163-R165}
}

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References

SHOWING 1-10 OF 21 REFERENCES
Ceramide in Apoptosis: A Revisited Role
The sphingolipid ceramide has recently emerged as a new transducer or modulator of apoptotic cell death. This function, however, has recently been challenged. Here, in the light of recent
Molecular machinery for non-vesicular trafficking of ceramide
TLDR
It is concluded that CERT mediates the intracellular trafficking of ceramide in a non-vesicular manner.
Ceramide in apoptosis: an overview and current perspectives.
Identification of a family of animal sphingomyelin synthases
TLDR
Using a functional cloning strategy in yeast, a novel family of integral membrane proteins exhibiting all enzymatic features previously attributed to animal SM synthase is identified, and these findings open up important new avenues for studying sphingolipid function in animals.
Sphingolipid transport in eukaryotic cells.
Raft ceramide in molecular medicine
TLDR
Preliminary data suggest that manipulation of Ceramide metabolism and/or the function of ceramide-enriched membrane platforms may present novel therapeutic opportunities for the treatment of cancer, degenerative disorders, pathogenic infections or cardiovascular diseases.
Yeast sphingolipids: metabolism and biology.
Cloning and Characterization of a Lysosomal Phospholipase A2, 1-O-Acylceramide Synthase*
TLDR
The replacement of serine with alanine in the lipase motif of mouse LLPL resulted in elimination of enzyme activity, indicating that the serine residue is part of the catalytic site.
Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.
...
...