Lipid Mediators in Acne

@article{Ottaviani2010LipidMI,
  title={Lipid Mediators in Acne},
  author={Monica Ottaviani and Emanuela Camera and Mauro Picardo},
  journal={Mediators of Inflammation},
  year={2010},
  volume={2010}
}
Multiple factors are involved in acne pathogenesis, and sebum secretion is one of the main ones. The role sebum plays in acne development has not been completely elucidated yet; however, increasing amounts of data seem to confirm the presence of alterations in sebum from acne patients. Altered ratio between saturated and unsaturated fatty acids has been indicated as an important feature to be considered in addition to the altered amount of specific fatty acids such as linoleic acid. Furthermore… 

Figures and Tables from this paper

Acne and Lipid Pathways

Findings indicate that sebum lipid fractions with proinflammatory properties and inflammatory tissue cascades are associated in the process of the development of acne lesions.

A review of the role of sebum in the mechanism of acne pathogenesis

Recent developments in lipidomics have provided effective lipid analysis methods that can help elucidate the effects of different types of sebum on acne occurrence and provide a theoretical basis for research on the mechanisms of acne pathogenesis and treatment.

Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions

Findings indicate that sebum lipid fractions with proinflammatory properties and inflammatory tissue cascades are associated in the process of the development of acne lesions.

The relevance of sebum composition in the etiopathogeny of acne

The aim of this study was to review the literature regarding the new concepts on the pathogenesis of acne to find out whether modifications in the sebum composition lead to a greater proliferation and differentiation of keratinocytes that obstruct the follicular ostium and favor the formation of comedones.

Acne and Antimicrobial Lipids

Evidence is provided that sebum quantity per se cannot be the only responsible factor for the development of acne, as demonstrated by the success of treatment with agents with no primary effect on sebum excretion rate.

Use of lipidomics to investigate sebum dysfunction in juvenile acne[S]

Overall, the data indicated an association between the clinical grading of acne and sebaceous lipid fingerprints and highlighted DGs as more abundant in sebum from adolescents affected with acne.

Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

Future treatment for acne should embrace approaches that target the main etiological factors of acne, and specific emphasis on aggressive treatment in the acute inflammatory phase to reduce the likelihood of scarring and other clinical sequelae, such as pigmentary changes would be highly desirable.

Commentary on ‘Sebocyte differentiation as a new target for acne therapy: an in vivo experience’

  • L. KeményK. Szabó
  • Biology, Medicine
    Journal of the European Academy of Dermatology and Venereology : JEADV
  • 2020
Investigation of the consequences of insulin treatment in human in vitro cultured immortalized sebocytes confirmed that the human sebum has a special species-specific composition, and showed that their differentiation is an important factor during acne pathogenesis.

Evidence for the Important ¬Role of Oxidative Stress in the Pathogenesis of Acne

It is believed that ROS can contribute significantly to the acne vulgaris pathobiology via toll-like receptor (TLR), peroxisome proliferator-activated receptor (PPAR), mTOR pathway, and innate immune system, resulting in inflammation by alterations in the generation of several proinflammatory cytokines including IL-1, IL-8, and TNF-α.

The role of inflammation in the pathology of acne.

  • E. Tanghetti
  • Biology, Medicine
    The Journal of clinical and aesthetic dermatology
  • 2013
Evidence is presented to support the notion that acne is primarily an inflammatory disease, challenging the current nomenclature of noninflammatory versus inflammatory acne lesions and suggesting that the nomenClature is outdated and incorrect.
...

References

SHOWING 1-10 OF 54 REFERENCES

A possible role for squalene in the pathogenesis of acne. I. In vitro study of squalene oxidation

The results clearly show that squalene is a highly effective oxygen‐scavenging agent and may first induce comedogenesis and, as a secondary event, cause a large reduction in oxygen tension in the human pilo‐sebaceous duct.

Essential fatty acids and acne.

Sebaceous gland lipids

Understanding the factors and mechanisms that regulate sebum production is needed in order to identify new targets that could be addressed to achieve a selective modulation of lipid biosynthesis as a novel therapeutic strategy to correct lipid disregulations in acne and other disorders of the pilosebaceous unit.

Is Acne vulgaris a Genuine Inflammatory Disease?

The role of P. acnes in acne cannot be explained by its presence in the follicle, and the number of follicular bacteria on untreated skin of acne patients does not correlate with the grade of severity of acne.

Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris.

The present data further support the involvement of lipid peroxides, in particular squalene peroxide, in establishing an inflammatory process in acne.

Accumulation of lipid peroxide in the content of comedones may be involved in the progression of comedogenesis and inflammatory changes in comedones

It is hypothesized that lipid accumulation in comedones induces progression of comedogenesis and inflammatory changes in Comedones, and the possible role of accumulated LPO in comedogenic and its inflammatory changes is investigated.

A possible role for squalene in the pathogenesis of acne. II. In vivo study of squalene oxides in skin surface and intra‐comedonal lipids of acne patients

Skin surface lipids and lipids from open and closed comedones in acne patients were analysed by thin layer chromatography. The results showed that these lipids were enriched in polar lipids, as

Peroxisome proliferator-activated receptors increase human sebum production.

Data indicate that PPARs play a role in regulating sebum production and that selective modulation of their activity may represent a novel therapeutic strategy for the treatment of acne.

Advances in sebaceous gland research: potential new approaches to acne management

Interestingly, retinoids, cytokines and nuclear hormone receptors appear to be promising inhibitors of sebum synthesis, thus offering new approaches to acne management.

The Human Sebocyte Culture Model Provides New Insights into Development and Management of Seborrhoea and Acne

Stimulation of sebocyte proliferation by insulin, thyroid-stimulating hormone and hydrocortisone indicates that the hormonal control of the sebaceous gland could be a complex mechanism.
...