Lipid-Mediated Insertion of Toll-Like Receptor (TLR) Ligands for Facile Immune Cell Engineering

  title={Lipid-Mediated Insertion of Toll-Like Receptor (TLR) Ligands for Facile Immune Cell Engineering},
  author={M. H. Zhang and Emily Slaby and Georgina Stephanie and Chunsong Yu and D. Watts and H. Liu and Gregory L Szeto},
  journal={Frontiers in Immunology},
  • M. H. Zhang, Emily Slaby, +4 authors Gregory L Szeto
  • Published 2020
  • Chemistry, Medicine
  • Frontiers in Immunology
  • Cell-based immunotherapies have tremendous potential to treat many diseases, such as activating immunity in cancer or suppressing it in autoimmune diseases. Most cell-based cancer immunotherapies in the clinic provide adjuvant signals through genetic engineering to enhance T cell functions. However, genetically encoded signals have minimal control over dosing and persist for the life of a cell lineage. These properties make it difficult to balance increasing therapeutic efficacy with reducing… CONTINUE READING


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