Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo

@article{Kovach1990LipidII,
  title={Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo},
  author={Nicholas L. Kovach and Emily Yee and Robert S. Munford and Christian R. H. Raetz and John Harlan},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={172},
  pages={77 - 84}
}
Tumor necrosis factor (TNF) released by lipopolysaccharide (LPS)-stimulated mononuclear phagocytes is a critical mediator of sepsis. We examined the capacities of rough mutant Salmonella typhimurium LPS (Rc) and LPS partial structures lipid A, monophosphoryl lipid A (MPLA), lipid IVA, and lipid X to induce production of TNF in whole blood. Rc LPS (0.0001-10 ng/ml) produced a dose-dependent release of TNF as determined by cytotoxicity of actinomycin D-sensitized L929 murine fibroblasts. Lipid A… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 30 references

ILl induction - capacity ofdefined lipopolysaccharide partial structures

K. E. Burhop J. A. Will
J . Immunol . • 1989

Medical Center, 325 Ninth Avenue, Seattle, WA 98104

Washington, Harborview
Received for publication • 1989

Purification of acylox- terial endotoxin

R. S. Munford, C. L . Hall
J. Infect . Dis • 1989

Takahishi, after endotoxin administration

S. Kotani, H. Takada, M. Tsjuimoto, I. T Ogawa
N. Engl. J. Med. 318:1481 • 1989

Induction of K light chain synthesis in 70 Z / 3 Blymphoma cells by chemically defined lipid A precursors

C. R. H. Raetz, S. Purcell
J . Biol . Chem . • 1988

endotoxin: a biologically active lipid

Raetz, C.R.H, +9 authors R. Y. Hampton
Harbor Symp Quant. Biol • 1988

Similar Papers

Loading similar papers…