Lipid Emulsion Infusion Rescues Dogs From Bupivacaine-Induced Cardiac Toxicity

@article{Weinberg2003LipidEI,
  title={Lipid Emulsion Infusion Rescues Dogs From Bupivacaine-Induced Cardiac Toxicity},
  author={Guy L. Weinberg and Richard Ripper and Douglas L. Feinstein and W Hoffman},
  journal={Regional Anesthesia \& Pain Medicine},
  year={2003},
  volume={28},
  pages={198 - 202}
}
Background and Objectives We previously demonstrated in rats that intravenous infusion of a lipid emulsion increases survival in resuscitation from severe bupivacaine cardiac toxicity. The present studies were undertaken to determine if this method is similarly effective in a non-rodent model using a larger animal. Methods Bupivacaine, 10 mg/kg, was administered intravenously over 10 seconds to fasted dogs under isoflurane general anesthesia. Resuscitation included 10 minutes of internal… 
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TLDR
The combination of lipid emulsion and ACLS did not improve survival from bupivacaine- and hypoxia-induced cardiovascular collapse in unanesthetized swine and there was no significant difference between groups of surviving animals in the time to ROSC.
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TLDR
Insulin effectively reversed the sudden-onset circulatory collapse in dogs caused by an intravenous bolus injection of bupivacaine in this randomized controlled study.
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