Lipid Emulsion Infusion Rescues Dogs From Bupivacaine-Induced Cardiac Toxicity

  title={Lipid Emulsion Infusion Rescues Dogs From Bupivacaine-Induced Cardiac Toxicity},
  author={Guy L. Weinberg and Richard Ripper and Douglas L. Feinstein and W Hoffman},
  journal={Regional Anesthesia \& Pain Medicine},
  pages={198 - 202}
Background and Objectives We previously demonstrated in rats that intravenous infusion of a lipid emulsion increases survival in resuscitation from severe bupivacaine cardiac toxicity. The present studies were undertaken to determine if this method is similarly effective in a non-rodent model using a larger animal. Methods Bupivacaine, 10 mg/kg, was administered intravenously over 10 seconds to fasted dogs under isoflurane general anesthesia. Resuscitation included 10 minutes of internal… 

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