Lipid Antioxidant, Etoposide, Inhibits Phosphatidylserine Externalization and Macrophage Clearance of Apoptotic Cells by Preventing Phosphatidylserine Oxidation*

@article{Tyurina2004LipidAE,
  title={Lipid Antioxidant, Etoposide, Inhibits Phosphatidylserine Externalization and Macrophage Clearance of Apoptotic Cells by Preventing Phosphatidylserine Oxidation*},
  author={Y. Tyurina and F. B. Serinkan and V. Tyurin and V. Kini and J. Yalowich and A. Schroit and B. Fadeel and V. Kagan},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={6056 - 6064}
}
  • Y. Tyurina, F. B. Serinkan, +5 authors V. Kagan
  • Published 2004
  • Biology, Medicine
  • Journal of Biological Chemistry
  • Apoptosis is associated with the externalization of phosphatidylserine (PS) in the plasma membrane and subsequent recognition of PS by specific macrophage receptors. Selective oxidation of PS precedes its externalization/recognition and is essential for the PS-dependent engulfment of apoptotic cells. Because etoposide is a potent and selective lipid antioxidant that does not block thiol oxidation, we hypothesized that it may affect PS externalization/recognition without affecting other features… CONTINUE READING
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