Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells

@article{Wang2018LipidAH,
  title={Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells},
  author={T. Wang and Yonghui Yu and Xiaofei Liang and Shengdong Luo and Zemin He and Z. Sun and Y. Jiang and Anders Omsland and P. Zhou and L. Song},
  journal={Frontiers in Cellular and Infection Microbiology},
  year={2018},
  volume={8}
}
  • T. Wang, Yonghui Yu, +7 authors L. Song
  • Published 2018
  • Chemistry, Medicine
  • Frontiers in Cellular and Infection Microbiology
Lipid A is an essential basal component of lipopolysaccharide of most Gram-negative bacteria. Inhibitors targeting LpxC, a conserved enzyme in lipid A biosynthesis, are antibiotic candidates against Gram-negative pathogens. Here we report the characterization of the role of lipid A in Coxiella burnetii growth in axenic media, monkey kidney cells (BGMK and Vero), and macrophage-like THP-1 cells by using a potent LpxC inhibitor -LPC-011. We first determined the susceptibility of C. burnetii LpxC… Expand
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