Lipid‐lowering efficacy of 3,4‐di(OH)‐phenylpropionic L‐leucine in high‐cholesterol fed rats

  title={Lipid‐lowering efficacy of 3,4‐di(OH)‐phenylpropionic L‐leucine in high‐cholesterol fed rats},
  author={Soon-ja Kim and Song Hae Bok and Sangku Lee and Mi-Kyung Lee and Yong Bok Park and Hye-Jin Kim and Myung‐Sook Choi},
  journal={Journal of Biochemical and Molecular Toxicology},
A preliminary study revealed that 3,4‐di(OH)‐hydrocinnamate (HC), a polyphenolic compound, lowered the plasma lipids in high‐cholesterol fed rats. Accordingly, this study was designed to test the lipid‐lowering efficacy of a synthetic derivative, 3,4‐di(OH)‐phenylpropionic (L‐leucine) amide (PPLA), in rats fed a high‐cholesterol (1%, wt/wt) diet. As such, HC or PPLA was given as supplement to a high‐cholesterol diet for 6 weeks at a dose of 0.137 mmol/100 g diet. The supplementation of HC and… 
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2,4,5-trimethoxycinnamic acid: the major metabolite of α-asarone, retains most of the pharmacological properties of α-asarone
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Effect of melatonin on cholesterol absorption in rats
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Lipid-lowering and antioxidative activities of 3,4-di(OH)-cinnamate and 3,4-di(OH)-hydrocinnamate in cholesterol-fed rats.
  • J. Lee, M. Choi, S. Bok
  • Biology
    Clinica chimica acta; international journal of clinical chemistry
  • 2001
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