Lipases specifically degrading lipopolysaccharide: fatty acyl amidases from Dictyostelium discoideum.

@article{Verret1984LipasesSD,
  title={Lipases specifically degrading lipopolysaccharide: fatty acyl amidases from Dictyostelium discoideum.},
  author={C. Reynold Verret},
  journal={Reviews of infectious diseases},
  year={1984},
  volume={6 4},
  pages={452-4}
}
Two specific fatty acyl amidases that hydrolyze lipopolysaccharide have been isolated from the slime mold Dictyostelium discoideum. Esterases as well as phosphatases acting on lipid A derivatives were also observed. The first amidase (I) hydrolyzes the fatty amide adjacent to the C-1 phosphate on the disaccharide backbone of lipid A. Amidase II cleaves the distal amide, but only after deacylation of the first site. The range of specificity and the structural determinants important to… CONTINUE READING