Lipase-mediated partial resolution of 1 , 2-diol and 2-alkanol derivatives : towards chiral building-blocks for pheromone synthesis


1,2-Propanediol 5, 1-chloro-2-propanol 8 and its related 2-O-acetate 9 were partially resolved by chemoenzymatic acetylation and deacetylation, in the presence of Pseudomonas ̄uorescens lipase (Amano P.; PFL), to (R)-(^)-1-acetoxy-2-propanol 6, (R)-(+)-2-acetoxy-1-chloropropane 9 and (R)-(^)-1-chloro-2-propanol 8, respectively. On the other hand, treatment… (More)

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