Lipase-catalyzed highly enantioselective kinetic resolution of boron-containing chiral alcohols.

Abstract

The first application of enzymes as catalysts to obtain optically pure boron compounds is described. The kinetic resolution of boron-containing chiral alcohols via enantioselective transesterification catalyzed by lipases was studied. Aromatic, allylic, and aliphatic secondary alcohols containing a boronate ester or boronic acid group were resolved by… (More)
DOI: 10.1021/ol901091f

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