Lipase catalysed Michael addition of secondary amines to acrylonitrile.

@article{Torre2004LipaseCM,
  title={Lipase catalysed Michael addition of secondary amines to acrylonitrile.},
  author={Oliver Torre and Ignacio Alfonso and Vicente Gotor},
  journal={Chemical communications},
  year={2004},
  volume={15},
  pages={1724-5}
}
A new enzymatic process is described. Different preparations of lipase B from Candida antarctica are able to catalyse Michael-type addition of secondary amines to acrylonitrile. This new reaction widens the applicability of these biocatalysts in organic synthesis. 

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All the compounds were spectroscopically characterised (1H, 13C NMR and MS) and analytically compared (GC) with true samples prepared by conventional methods. The reactions

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