Lipase-Catalysed Addition of Pyrrolidine to Chalcone and Benzylidene Malonate Derivatives

Abstract

The porcine pancreas lipase (PPL) type II catalyzes the aminolysis of benzylidene malonates by regiospecific amidation of substrates and afforded the Z-isomer; no E-isomer or diamide byproducts were observed. PPL also catalyzes Michael addition of acetophenone to various derivatives of chalcones.

DOI: 10.1007/s10600-015-1434-1

Cite this paper

@article{Habibi2015LipaseCatalysedAO, title={Lipase-Catalysed Addition of Pyrrolidine to Chalcone and Benzylidene Malonate Derivatives}, author={Zohreh Habibi and Mortaza Yousefi and Rasool Kheyrabadi and Marzia Mohammadi and Mehrnush Moemeni and Shekeba Nazari}, journal={Chemistry of Natural Compounds}, year={2015}, volume={51}, pages={861-864} }