Lipase‐catalyzed process for biodiesel production: Protein engineering and lipase production

@article{Hwang2014LipasecatalyzedPF,
  title={Lipase‐catalyzed process for biodiesel production: Protein engineering and lipase production},
  author={Hyun Tae Hwang and Feng Qi and Chongli Yuan and Xuebing Zhao and Doraiswami Ramkrishna and De-hua Liu and Arvind Varma},
  journal={Biotechnology and Bioengineering},
  year={2014},
  volume={111}
}
  • H. Hwang, F. Qi, +4 authors A. Varma
  • Published 1 April 2014
  • Biology, Engineering
  • Biotechnology and Bioengineering
Biodiesel is an environment‐friendly and renewable fuel produced by transesterification of various feedstocks. Although the lipase‐catalyzed biodiesel production has many advantages over the conventional alkali catalyzed process, its industrial applications have been limited by high‐cost and low‐stability of lipase enzymes. This review provides a general overview of the recent advances in lipase engineering, including both protein modification and production. Recent advances in biotechnology… 
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The latest advances on lipase transesterification and key operational variables for an efficient biodiesel production from animal fat waste are reviewed.
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This article suggests that different mechanisms can lead to inactivation of different lipases, in particular substrate inhibition and protein unfolding, and attempts to improve the performances of methanol sensitive lipases by mutagenesis as well as process engineering approaches are suggested.
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TLDR
The progress achieved in enzymatic biodiesel research and commercialization is summarized, including reducing enzyme cost, expanding low-quality raw materials, and novel reactor designs.
Direct production of a genetically-encoded immobilized biodiesel catalyst
TLDR
A novel approach is reported that allows for the direct production of a highly active immobilized lipase within the bacterium Bacillus thuringiensis, resulting in a highly efficient fusion crystal that could catalyze the conversion of triacylglycerols to fatty acid methyl ester biodiesel to near-completion over 10 cycles.
Enzymatic transesterification for biodiesel production from used cooking oil, a review
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