Corpus ID: 18278893

Lion ’ s Mane ( Hericium erinaceus : Effects on Cognitive Function by

  title={Lion ’ s Mane ( Hericium erinaceus : Effects on Cognitive Function by},
  author={S. Farrar},
The Lion’s Mane mushroom (Hericium erinaceus) has been reported to support the function and health of the nervous system and has been the subject of several studies investigating the use of various compounds contained in the mushroom for the treatment of various neurodegenerative diseases, declines in cognitive function and injuries to the spine and nervous system. This mushroom has been highly valued in Traditional Chinese Medicine for thousands of years and contains many types of biologically… Expand


Compounds for dementia from Hericium erinaceum
In a recent study, dilinoleoyl-phosphatidylethanolamine (DLPE) was isolated from the mushroom and was found to protect against neuronal cell death caused by β-amyloid peptide (Aβ) toxicity, endoplasmic reticulum (ER) stress and oxidative stress. Expand
Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice.
The mushroom Hericium erinaceus prevented impairments of spatial short-term and visual recognition memory induced by amyloid β(25-35) peptide, indicating that H. erinACEus may be useful in the prevention of cognitive dysfunction. Expand
Amycenone, a nootropic found in Hericium erinaceum
Amycenone, which is an activator of brain function that is obtained from extracts of the Yamabushitake, has been found to pass through the blood–brain barrier, and its safety as a health food is currently being ascertained. Expand
Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake.
The results show that HE intake has the possibility to reduce depression and anxiety and these results suggest a different mechanism from NGF-enhancing action of H. erinaceus. Expand
Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (higher Basidiomycetes), in the treatment of peripheral nerve injury (review).
Analysis of walking track indicated that return of hind limb function and normal toe spreading occurred earlier in treated groups than in the negative control (non-treated) group, and daily oral administration of H. erinaceus could promote the regeneration of injured rat peroneal nerve in the early stage of recovery. Expand
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double‐blind placebo‐controlled clinical trial
The results obtained in this study suggest that Yamabushitake is effective in improving mild cognitive impaired men and women diagnosed with mild cognitive impairment. Expand
Hericenones C, D and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum
Abstract Novel compounds, hericenones C ( 3 ), D ( 4 ) and ( 5 ) were isolated from the mushroom Hericium erinaceum . These structures were determined by interpretation of the spectral data, andExpand
Nerve growth factor-inducing activity of Hericium erinaceus in 1321N1 human astrocytoma cells.
H. erinaceus contains active compounds that stimulate NGF synthesis via activation of the JNK pathway; these compounds are not hericenones. Expand
Hericenones and erinacines: stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus
This review surveys the chemical and biological literature dealing with the isolation, structural elucidation and bioactivity of hericenones and erinacines from the fruiting body and mycelium ofExpand
The influence of Hericium erinaceus extract on myelination process in vitro.
Myelin sheaths, wrapping axons, perform the following important functions: support, protection, feeding and isolation. Injury of myelin compact structure leads to an impairment and severe illness ofExpand