Linum narbonense: A new valuable tool for biotechnological production of a potent anticancer lignan Justicidine B

@article{Ionkova2013LinumNA,
  title={Linum narbonense: A new valuable tool for biotechnological production of a potent anticancer lignan Justicidine B},
  author={I. Ionkova and P. Sasheva and Todor Ionkov and G. Momekov},
  journal={Pharmacognosy Magazine},
  year={2013},
  volume={9},
  pages={39 - 44}
}
Background: Arylnaphthalene lignan Justicidin B is a lead compound in the management of bone cancer and osteoclastogenesis. The compound is the main cytotoxic principle of rare medicinal plant Linum narbonense L. (Linaceae). However, there have been no reports on the bioreactor production of justicidin B. Objective: to develop cost-effective biotechnology for production of this anticancer metabolite. Materials and Methods: The genetic transformation in hairy roots induced by Agrobacterium… Expand
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