Linopirdine. A depolarization-activated releaser of transmitters for treatment of dementia.

@article{Tam1995LinopirdineAD,
  title={Linopirdine. A depolarization-activated releaser of transmitters for treatment of dementia.},
  author={Sun W. Tam and Robert C. Zaczek},
  journal={Advances in experimental medicine and biology},
  year={1995},
  volume={363},
  pages={47-56}
}
Linopirdine (DuP 996, AVIVA), currently in Phase III clinical trial for the treatment of Alzheimer's disease, is a representative of a class of novel molecules which enhances the stimulus-evoked but not basal release of several neurotransmitters including ACh, DA, 5-HT and Glu. Linopiridine has been shown to enhance ACh release in the hippocampus in vivo. In addition, linopiridine produces a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-2 of 2 extracted citations

Similar Papers

Loading similar papers…