Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats.

@article{LangLazdunski2003LinolenicAP,
  title={Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats.},
  author={Lo{\"i}c Lang-Lazdunski and Nicolas Blondeau and Gis{\`e}le Jarretou and Michel Lazdunski and Catherine Heurteaux},
  journal={Journal of vascular surgery},
  year={2003},
  volume={38 3},
  pages={564-75}
}
PURPOSE Spinal cord ischemia is a devastating complication of thoracic and thoracoabdominal aortic surgery. Recent studies have suggested a neuroprotective effect of polyunsaturated fatty acids against cerebral ischemia. We investigated the effect of linolenic acid (LIN) in a rat model of spinal cord ischemia. METHODS Rats were subjected to cross-clamping of the aortic arch and left subclavian artery for 14 minutes. Groups were as follows: sham operation (n = 15); ischemia (n = 15), receiving… CONTINUE READING

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