• Biology, Medicine
  • Published in
    The Journal of biological…
    1987

Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor.

@article{Bandyopadhyay1987LinoleateME,
  title={Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor.},
  author={Gautam Kumar Bandyopadhyay and Walter Imagawa and D R Wallace and Satyabrata Nandi},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 6},
  pages={
          2750-6
        }
}
Linoleic acid, arachidonic acid, prostaglandin E1, and prostaglandin E2 stimulated the proliferation of mammary epithelial cells in serum-free primary cultures only in the presence of epidermal growth factor. Linoleate-stimulated growth was manifest later in culture when proliferation, initiated by epidermal growth factor only, reached a plateau while linoleate-supplemented epidermal growth factor cultures continued to proliferate. The cultures in the plateau phase of growth could be… CONTINUE READING

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