Linkup of a fast protein liquid chromatography system with a stirred thermostated cell for sterile preparation of liposomes by the proliposome-liposome method: application to encapsulation of antibiotics, synthetic peptide immunomodulators, and a photosensitizer.

@article{Turnek1997LinkupOA,
  title={Linkup of a fast protein liquid chromatography system with a stirred thermostated cell for sterile preparation of liposomes by the proliposome-liposome method: application to encapsulation of antibiotics, synthetic peptide immunomodulators, and a photosensitizer.},
  author={Jaroslav Tur{\'a}nek and Dana Z{\'a}lusk{\'a} and Jiř{\'i} Ne{\vc}a},
  journal={Analytical biochemistry},
  year={1997},
  volume={249 2},
  pages={
          131-9
        }
}
The proliposome-liposome method is based on the conversion of the initial proliposome preparation into a liposome dispersion by dilution with the aqueous phase. This technique is characterized by an extremely high entrapment efficiency and is suitable for the encapsulation of a wide range of drugs with different water and alcohol solubility. A description of a home-made stirred thermostated cell and its linkup with an FPLC system for a rapid and automated preparation of multilamellar liposomes… CONTINUE READING
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