Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion.

  title={Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion.},
  author={M J Williams and Andrew D Clouston and Stuart J Forbes},
  volume={146 2},
Interactions between cells and their extracellular matrix have been shown to be crucial in a wide range of biological processes, including the proliferation and differentiation of stem cells. Ductular reactions containing both hepatic progenitor cells and extracellular matrix are seen in response to acute severe and chronic liver injury. Understanding the molecular mechanisms whereby cell-matrix interactions regulate liver regeneration may allow novel strategies to enhance this process. Both… CONTINUE READING
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