Links between DNA Replication, Stem Cells and Cancer

@inproceedings{Vassilev2017LinksBD,
  title={Links between DNA Replication, Stem Cells and Cancer},
  author={Alex P Vassilev and Melvin L. Depamphilis},
  booktitle={Genes},
  year={2017}
}
Cancers can be categorized into two groups: those whose frequency increases with age, and those resulting from errors during mammalian development. The first group is linked to DNA replication through the accumulation of genetic mutations that occur during proliferation of developmentally acquired stem cells that give rise to and maintain tissues and organs. These mutations, which result from DNA replication errors as well as environmental insults, fall into two categories; cancer driver… CONTINUE READING
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