Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment.

@article{Leoni2010LinksBA,
  title={Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment.},
  author={Valerio Leoni and Alina Solomon and Miia Kivipelto},
  journal={Biochemical Society transactions},
  year={2010},
  volume={38 4},
  pages={1021-5}
}
Brain neurons remove the excess of cholesterol via conversion into the more polar 24OHC [(24S)-hydroxycholesterol]. 24OHC acts as a signalling molecule inducing ApoE (apolipoprotein E)-mediated cholesterol efflux from astrocytes, by a direct effect on ApoE transcription, protein synthesis and secretion. In CSF (cerebrospinal fluid) collected form from patients with cognitive impairment (Alzheimer's disease and patients with mild cognitive impairment) the levels of ApoE, tau, p-tau… CONTINUE READING

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