Linking white matter integrity loss to associated cortical regions using structural connectivity information in Alzheimer's disease and fronto-temporal dementia: The Loss in Connectivity (LoCo) score

@article{Kuceyeski2012LinkingWM,
  title={Linking white matter integrity loss to associated cortical regions using structural connectivity information in Alzheimer's disease and fronto-temporal dementia: The Loss in Connectivity (LoCo) score},
  author={Amy Kuceyeski and Yu Zhang and Ashish Raj},
  journal={NeuroImage},
  year={2012},
  volume={61},
  pages={1311-1323}
}
It is well known that gray matter changes occur in neurodegenerative diseases like Alzheimer's (AD) and fronto-temporal dementia (FTD), and several studies have investigated their respective patterns of atrophy progression. Recent work, however, has revealed that diffusion MRI that is able to detect white matter integrity changes may be an earlier or more sensitive biomarker in both diseases. However, studies that examine white matter changes only are limited in that they do not provide the… CONTINUE READING
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