Linking uric acid metabolism to diabetic complications.

  title={Linking uric acid metabolism to diabetic complications.},
  author={Akifumi Kushiyama and Kentaro Tanaka and Shigeko Hara and Shoji Kawazu},
  journal={World journal of diabetes},
  volume={5 6},
Hyperuricemia have been thought to be caused by the ingestion of large amounts of purines, and prevention or treatment of hyperuricemia has intended to prevent gout. Xanthine dehydrogenase/xanthine oxidase (XDH/XO) is rate-limiting enzyme of uric acid generation, and allopurinol was developed as a uric acid (UA) generation inhibitor in the 1950s and has been routinely used for gout prevention since then. Serum UA levels are an important risk factor of disease progression for various diseases… CONTINUE READING


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