Linking the nutritional status of Streptococcus pyogenes to alteration of transcriptional gene expression: the action of CodY and RelA.

@article{Malke2006LinkingTN,
  title={Linking the nutritional status of Streptococcus pyogenes to alteration of transcriptional gene expression: the action of CodY and RelA.},
  author={Horst Malke and Kerstin Steiner and William M. McShan and Joseph J. Ferretti},
  journal={International journal of medical microbiology : IJMM},
  year={2006},
  volume={296 4-5},
  pages={259-75}
}
In this investigation, we identify the CodY protein from Streptococcus pyogenes as a pleiotropic transcription regulator with global features. The notion that acquisition of nutrients by this polyauxotrophic organism is the primary event occurring during the establishment of infection and that virulence expression is a result of this quest, led us to study the action of codY and relA genes on transcriptional gene expression under different nutritional conditions using complex and chemically… CONTINUE READING

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