Linking the DNA strand asymmetry to the spatio-temporal replication program. I. About the role of the replication fork polarity in genome evolution.

@article{Baker2012LinkingTD,
  title={Linking the DNA strand asymmetry to the spatio-temporal replication program. I. About the role of the replication fork polarity in genome evolution.},
  author={Antoine Baker and Hanna Julienne and Chunlong L Chen and Benjamin Audit and Yves D'Aubenton-Carafa and Claude Thermes and Alain Arneodo},
  journal={The European physical journal. E, Soft matter},
  year={2012},
  volume={35 9},
  pages={92}
}
Two key cellular processes, namely transcription and replication, require the opening of the DNA double helix and act differently on the two DNA strands, generating different mutational patterns (mutational asymmetry) that may result, after long evolutionary time, in different nucleotide compositions on the two DNA strands (compositional asymmetry). We elaborate on the simplest model of neutral substitution rates that takes into account the strand asymmetries generated by the transcription and… CONTINUE READING
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