Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis.

@article{Yule2010LinkingST,
  title={Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis.},
  author={David I. Yule and Matthew John Betzenhauser and Suresh K. Joseph},
  journal={Cell calcium},
  year={2010},
  volume={47 6},
  pages={
          469-79
        }
}
Great insight has been gained into the structure and function of the inositol 1,4,5 trisphosphate receptor (InsP(3)R) by studies employing mutagenesis of the cDNA encoding the receptor. Notably, early studies using this approach defined the key constituents required for InsP(3) binding in the N-terminus and the membrane spanning regions in the C-terminal domain responsible for channel formation, targeting and function. In this article we evaluate recent studies which have used a similar… CONTINUE READING
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