Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease.

@article{Somasundaram2012LinkingRC,
  title={Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease.},
  author={Rajesh Somasundaram and J. Jasper Deuring and Christine P J van der Woude and Maikel P Peppelenbosch and Gwenny M Fuhler},
  journal={Gut},
  year={2012},
  volume={61 7},
  pages={1097; author reply 1097-8}
}
We read with interest the paper from Muise et al in which they describe a rare variant in the NCF2 gene, which demonstrates a diminished RAC2 binding capacity. The NCF2 encoded protein p67 is one of the components of the NADPH oxidase complex which drives the production of reactive oxygen species (ROS) during the bactericidal response of innate immune cells… CONTINUE READING