Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)

@article{Fang2009LinkingNA,
  title={Linking neuron and skin: Matrix metalloproteinases in amyotrophic lateral sclerosis (ALS)},
  author={Lubin Fang and Friederike Huber-Abel and Marko Teuchert and Corinna Hendrich and Johannes Brettschneider},
  journal={Journal of the Neurological Sciences},
  year={2009},
  volume={285},
  pages={62-66}
}
Amyotrophic lateral sclerosis (ALS) mainly affects the motor neurons but may also include other organs such as the skin. We aimed to determine whether matrix metalloproteinases could provide a link between neuronal degeneration and skin alterations in ALS. We measured CSF, serum and skin tissue MMP-2 and MMP-9 using ELISA and malondialdehyde (MDA), a marker of lipid peroxidation, using High Performance Liquid Chromatography (HPLC) in 54 ALS patients and 36 controls. We found CSF and skin MMP-9… CONTINUE READING

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