Linking iodine with autoimmune thyroiditis.
@article{Rose1999LinkingIW, title={Linking iodine with autoimmune thyroiditis.}, author={N. Rose and L. Rasooly and A. M. Saboori and C. L. Burek}, journal={Environmental Health Perspectives}, year={1999}, volume={107}, pages={749 - 752} }
A great deal of circumstantial evidence has linked iodine with the rising incidence of autoimmune thyroiditis in the United States. In our investigations, we have shown directly that T cells from humans with chronic lymphocytic thyroiditis proliferate in the presence of iodinated but not in the presence of noniodinated human thyroglobulin. Moreover, the proliferative response is restored when the thyroglobulin is iodinated artificially in vitro. Using a panel of monoclonal antibodies, we found… CONTINUE READING
Topics from this paper
51 Citations
Iodination of murine thyroglobulin enhances autoimmune reactivity in the NOD.H2h4 mouse
- Chemistry, Medicine
- Clinical and experimental immunology
- 2005
- 41
Molecular parameters linking thyroglobulin iodination with autoimmune thyroiditis
- Medicine
- Hormones
- 2011
- 27
- PDF
Evolution of thyroid autoimmunity during iodine prophylaxis--the Sri Lankan experience.
- Medicine
- European journal of endocrinology
- 2003
- 46
- PDF
High prevalence of autoimmune thyroiditis in schoolchildren after elimination of iodine deficiency in northwestern Greece.
- Medicine
- Thyroid : official journal of the American Thyroid Association
- 2003
- 158
- PDF
High prevalence of thyroid dysfunction and autoimmune thyroiditis in adolescents after elimination of iodine deficiency in the Eastern Black Sea Region of Turkey.
- Medicine
- Thyroid : official journal of the American Thyroid Association
- 2006
- 28
- PDF
[Pathogenesis of autoimmune thyroid diseases].
- Medicine
- Arquivos brasileiros de endocrinologia e metabologia
- 2009
- 11
- PDF
References
SHOWING 1-10 OF 55 REFERENCES
The role of iodine in thyroid autoimmunity: from chickens to humans: a review.
- Medicine
- Autoimmunity
- 1992
- 87
Iodine-induced autoimmune thyroiditis in NOD-H-2h4 mice.
- Medicine
- Clinical immunology and immunopathology
- 1996
- 203
Iodination of human thyroglobulin (Tg) alters its immunoreactivity. I. Iodination alters multiple epitopes of human Tg
- Chemistry, Medicine
- Clinical and experimental immunology
- 1998
- 72
Enhanced susceptibility to iodide myxedema in patients with Hashimoto's disease.
- Medicine
- The Journal of clinical endocrinology and metabolism
- 1971
- 173
- PDF
Studies of hypothyroidism in patients with high iodine intake.
- Chemistry, Medicine
- The Journal of clinical endocrinology and metabolism
- 1986
- 115
Prevalence of Hypothyroidism and Hashimoto’s Thyroiditis in Two Elderly Populations with Different Dietary Iodine Intake
- Medicine
- 1987
- 15
Iodine-induced subclinical hypothyroidism in euthyroid subjects with a previous episode of amiodarone-induced thyrotoxicosis.
- Medicine
- The Journal of clinical endocrinology and metabolism
- 1992
- 48