Linking genetic susceptibility and T cell activation in beryllium-induced disease.

@article{Falta2010LinkingGS,
  title={Linking genetic susceptibility and T cell activation in beryllium-induced disease.},
  author={Michael T Falta and Natalie A. Bowerman and Shaodong Dai and John W. Kappler and Andrew P Fontenot},
  journal={Proceedings of the American Thoracic Society},
  year={2010},
  volume={7 2},
  pages={126-9}
}
Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by beryllium (Be) exposure in the workplace. It is characterized by the accumulation of Be-specific CD4(+) T cells in the lung as well as persistent lung inflammation, culminating in the development of lung fibrosis. CBD occurs in 2 to 16% of Be-exposed workers depending on the individuals' genetic susceptibility and the characteristics of the exposure. Genetic susceptibility to Be-induced disease has been linked to major… CONTINUE READING