Linking cellular activation to cytoskeletal reorganization: Wiskott-Aldrich syndrome as a model.

@article{Stewart2001LinkingCA,
  title={Linking cellular activation to cytoskeletal reorganization: Wiskott-Aldrich syndrome as a model.},
  author={Donn M. Stewart and Lan Tian and David L. G. Nelson},
  journal={Current opinion in allergy and clinical immunology},
  year={2001},
  volume={1 6},
  pages={525-33}
}
The Wiskott-Aldrich syndrome is an inherited X-linked disorder characterized by immune deficiency, eczema, and thrombocytopenia with small platelets. The mutated protein, Wiskott-Aldrich syndrome protein, is an activator of actin cytoskeletal reorganization in hematopoietic cells. Members of the Wiskott-Aldrich syndrome protein family are being shown to be key integrators of cell signalling and cytoskeletal organization in many eukaryotic cell types. This review focuses on recent discoveries… CONTINUE READING