Linking cell structure to gene regulation: signaling events and expression controls on the model genes PAI-1 and CTGF.

@article{Samarakoon2010LinkingCS,
  title={Linking cell structure to gene regulation: signaling events and expression controls on the model genes PAI-1 and CTGF.},
  author={Rohan Samarakoon and Margarete Goppelt-Struebe and Paul J. Higgins},
  journal={Cellular signalling},
  year={2010},
  volume={22 10},
  pages={
          1413-9
        }
}
The microtubule and microfilament cytoskeletal systems as well as cell-to-cell contacts and cell-matrix interactions are critical regulators of cell structure and function. Alterations in cell shape profoundly influence signaling events and gene expression programs that impact a spectrum of biological responses including cell growth, migration and apoptosis. These same pathways also contribute to the progression of several important pathologic conditions (e.g., arteriosclerosis, vascular… CONTINUE READING
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