Linking cell signaling and the epigenetic machinery

  title={Linking cell signaling and the epigenetic machinery},
  author={Helai P. Mohammad and Stephen B. Baylin},
  journal={Nature Biotechnology},
One of the biggest gaps in our knowledge about epigenomes is how their interplay with cellular signaling influences development, adult cellular differentiation and disease. 

The versatile regulation of cellular events by Jak-Stat signaling: from transcriptional control to microtubule dynamics and energy metabolism

No abstract available.

Metabolic regulation of epigenetics.

Integrin-epigenetics: a system with imperative impact on cancer

Influences of integrin signaling along with their epigenetic relationship on other signals of a normal functioning cell and its dysregulation in cancer are discussed.

Beyond Hit-and-Run: Stem Cells Leave a Lasting Memory.

Epigenetic disruption of cell signaling in nasopharyngeal carcinoma

The epigenetic deregulation of cell signaling in NPC tumorigenesis is summarized and the importance of identifying epigenetic cell signaling regulators in NPC research is highlighted, with a view to developing pharmacologic strategies to reverse the epigenetic-silencing ofcell signaling regulators.

Epigenetics and bacterial infections.

The molecular bases of the epigenetic language are reviewed and the current state of research regarding how bacteria can alter epigenetic marks and machineries are described.

Epigenetics in non-small cell lung carcinomas.

Several epigenetic complexes and mechanisms must be analyzed and considered for the design of new and efficient therapies, which could be fundamental to develop an integrated knowledge to achieve a comprehensive lung cancer personalized medicine.

Flickin’ the ubiquitin switch

A broad overview of the pathways known to be regulated by H2B ubiquitylation is presented, while drawing parallels between findings in disparate organisms, in order to facilitate continued delineation of its spatiotemporal role in development.

Helper T‐cell differentiation and plasticity: insights from epigenetics

Recent progress in the understanding of how cytokines influence gene expression and epigenetic modifications is discussed, and the impact of these findings on the authors' views of helper cell lineage commitment and plasticity is discussed.

Epigenetic memory in development and disease: Unraveling the mechanism.




Tackling the epigenome: challenges and opportunities for collaboration

What are the key considerations to take into account when large-scale epigenomics projects are being implemented?

Pluripotent Chromatin State

Chromatin in pluripotent embryonic stem cells may act as a buffer to transcriptional noise in order to protect against cell reprograming errors.

Notch signalling: a simple pathway becomes complex

  • S. Bray
  • Biology
    Nature Reviews Molecular Cell Biology
  • 2006
Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.

Epigenetic stem cell signature in cancer

It is reported that stem cell Polycomb group targets are up to 12-fold more likely to have cancer-specific promoter DNA hypermethylation than non-targets, supporting a stem cell origin of cancer in which reversible gene repression is replaced by permanent silencing, locking the cell into a perpetual state of self-renewal and thereby predisposing to subsequent malignant transformation.

Gene silencing in cancer in association with promoter hypermethylation.

The mechanisms of gene silencing in cancer and clinical applications of this phenomenon are reviewed, especially tumor-suppressor genes.