Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans.

Abstract

How asymmetric divisions are connected to the terminal differentiation program of neuronal subtypes is poorly understood. In C. elegans, two homeodomain transcription factors, TTX-3 (a LHX2/9 ortholog) and CEH-10 (a CHX10 ortholog), directly activate a large battery of terminal differentiation genes in the cholinergic interneuron AIY. We establish here a… (More)
DOI: 10.1016/j.devcel.2009.02.011

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