Linking an insect enzyme to hypertension: angiotensin II-epoxide hydrolase interactions.

@article{Ai2010LinkingAI,
  title={Linking an insect enzyme to hypertension: angiotensin II-epoxide hydrolase interactions.},
  author={Ding Ai and John Y-J Shyy and Yi Zhu},
  journal={Kidney international},
  year={2010},
  volume={77 2},
  pages={88-92}
}
Derived from arachidonic acid, epoxyeicosatrienoic acids function as antihypertensive and antihypertrophic mediators in the cardiovascular system. Epoxyeicosatrienoic acids are generated by soluble epoxide hydrolase, an enzyme hydrolyzing the epoxide moiety of juvenile hormones in insects, and are endothelium-derived hyperpolarizing factors that induce vessel dilation for cardioprotection. Pharmacological inhibition and genetic ablation of soluble epoxide hydrolase increases the level of… CONTINUE READING